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KMID : 0604520170430030201
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Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 3 p.201 ~ p.210
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Enhancement of Antioxidant and Whitening Effect of Fermented Extracts of Scutellariae baicalensis
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Um Ji-Na
Min Jin-Woo
Joo Kwang-Sik
Kang Hee-Cheol
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Abstract
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Scutellariae baicalensis (S. baicalensis) has been traditionally used for anti-inflammatory effect. This study was designed to compare the antioxidant and whitening effects of S. baicalensis extract and its fermented extract by Leuconostoc mesenteroides (L. mesenteroides). Fermented extract of S. baicalenins was prepared by inoculation of L. mesenteroides after the extraction procedure with 70% ethanol. S. baicalensis extract and its fermented extract was investigated via high-performance liquid chromatography (HPLC). Simultaneous qualitative analysis of two bioactive components; baicalin and baicalein was achieved by comparing their retention times (tR) and UV spectra with those of the standard components. Cell viability test results indicated that both S. baicalensis extract and its fermented extract were non-toxicity. In DPPH radical scavenging ability, SC50 values of the fermented extract was 34.43 μg/mL as a result of more effective than S. baicalensis extract. In nontoxic concentration rage, fermented extract of S. baicalensis showed strong melanin production inhibitory effect in α-melanocyte stimulating hormone (MSH)-stimulated B16F10 cell (IC50 = 68.17 μg/mL). These results suggested that fermented extracts of S. baicalensis has considerable potential as a cosmetics ingredient with an antioxidant and anti-wrinkle and whitening effects.
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KEYWORD
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antioxidant , baicalein , baicalin , Leuconostoc mesenteroides , Scutellariae baicalensis , whitening effect
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